p-Toluenesulfonic acid → N,N-dimethyl-2-(4-oxocyclohexyl)acetamide
反応式
C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:12][N:13]([CH3:27])[C:14](=[O:26])[CH2:15][CH:16]1[CH2:25][CH2:24][C:19]2(OCC[O:20]2)[CH2:18][CH2:17]1>CC(C)=O>[CH3:27][N:13]([CH3:12])[C:14](=[O:26])[CH2:15][CH:16]1[CH2:25][CH2:24][C:19](=[O:20])[CH2:18][CH2:17]1参加物
4
実験手順
p-Toluenesulfonic acid (84 mg) is added to a solution of N,N-dimethyl-2-(1,4-dioxaspiro[4.5]decan-8-yl)acetamide (500 mg) in acetone (10 ml) and the mixture is heated under reflux for 3 hours. The solvent is removed under reduced pressure. The residue is dissolved in CH2Cl2 and washed with water. The organic layer is dried (Na2SO4) and filtered, and the solvent is removed under reduced pressure to give N,N-dimethyl-2-(4-oxocyclohexyl)acetamide (400 mg).
後処理
- temperaturethe mixture is heated
- temperatureunder reflux for 3 hours
- customThe solvent is removed under reduced pressure
- dissolutionThe residue is dissolved in CH2Cl2
- washwashed with water
- dry with materialThe organic layer is dried (Na2SO4)
- filtrationfiltered
- customthe solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-51a304ae37d4451fb65828b5bd44e609
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653262B2
反応ノート
読み込み中…