Hydrochloric Acid → Phthalylglycine aldehyde

HRID 243588

反応式

HRID 243588 の反応式
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[C:18](OCC)(=[O:20])[CH3:19]>O1CCCC1>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:19][CH:18]=[O:20]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 66899166Phthalimide diethylacetal

生成物 1

HCID 76201Phthalylglycine aldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
75 °C

実験手順

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to RT, and ethyl acetate (100 mL) was added. The solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL), and the organic layer was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

後処理

  1. temperatureto cool to RT
  2. extractionThe solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL)
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate (MgSO4)
  5. filtrationThe solution was filtered
  6. customevaporated

出典と根拠

ORDレコード
ord-7c1115ba6deb4bdea03b4f40c87e0f17
出典データセット
uspto-grants-2014_02
特許番号
US08653141B2

関連ノート

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