Trifluoroacetic acid → (3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid

HRID 243714ノート

反応式

HRID 243714 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]([O:11]C(C)(C)C)=[O:10])[C:3]1=[O:16].C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]([OH:11])=[O:10])[C:3]1=[O:16]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59011720Tert-butyl(3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate

生成物 1

HCID 57907519(3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid収率 1,012.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 0.090 g (0.39 mmol) of tert-butyl (3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate from step B above in 4 mL of anhydrous dichloromethane was added 1 mL of TFA. The resulting mixture was stirred at ambient temperature for 6 h then evaporated to dryness in vacuo to afford the title compound as an off-white gum (0.68 g, 99%). LC-MS: m/z (ES) 173 (MH)+.

後処理

  1. customthen evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-ced8246261cd48b1b81f4e09c42d593e
出典データセット
uspto-grants-2014_02
特許番号
US08653260B2

反応ノート

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