(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol → (3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

HRID 243797ノート

反応式

HRID 243797 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([N+:15]([O-])=O)[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[NH2:15][C:7]1[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=1

参加物

4

反応物 1

HCID 58493934(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol

生成物 1

HCID 58366895(3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of (5-tert-butyl-2-methoxy-3-nitrophenyl)methanol (0.250 g, 1.04 mmol) in ethyl acetate (10.4 mL), 10% palladium/activated charcoal (0.025 g) was added and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 14 hours. After completion of the reaction, insoluble materials were filtered through a Celite pad, and the solvent was washed with ethyl acetate. The solvent of the filtrate was evaporated under reduced pressure to obtain 0.219 g (quantitative) of the crude product containing the captioned compound.

後処理

  1. customAfter completion of the reaction, insoluble materials
  2. filtrationwere filtered through a Celite pad
  3. washthe solvent was washed with ethyl acetate
  4. customThe solvent of the filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b3b8e79bbc504cba9f693ebbff4c6a6a
出典データセット
uspto-grants-2014_02
特許番号
US08653304B2

反応ノート

読み込み中…