Water → 5-(2-Chloroethyl)Oxindole

HRID 24380ノート

反応式

HRID 24380 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.C([SiH](CC)CC)C.O>FC(F)(F)C(O)=O>[Cl:1][CH2:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2

参加物

5

反応物 3

HCID 962WaterHCID 12052TriethylsilaneHCID 20605765-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 145813925-(2-Chloroethyl)Oxindole収率 65%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 5-chloroacetyl-2-oxindole (4.18 g) in trifluoroacetic acid (30 ml) was cooled in an ice bath and 4.65 g of triethylsilane added. The mixture was then stirred at room temperature for 3 hours. The mixture was poured into 150 ml of water and the precipitate which formed was collected by vacuum filtration, washed with 50 ml of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.

後処理

  1. customthe precipitate which formed
  2. filtrationwas collected by vacuum filtration
  3. washwashed with 50 ml of water
  4. customdried

出典と根拠

ORDレコード
ord-5e8a1e2bb0f9481c9e511871bbe592ce
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

反応ノート

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