p-Cyanobenzyl alcohol → N-Hydroxy-4-(hydroxymethyl)benzimidamide

HRID 243821ノート

反応式

HRID 243821 の反応式
Cl.[NH2:2][OH:3].[OH:4][CH2:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.C(=O)([O-])O.[Na+]>CO>[OH:3][N:2]=[C:10]([C:9]1[CH:12]=[CH:13][C:6]([CH2:5][OH:4])=[CH:7][CH:8]=1)[NH2:11]

参加物

5

反応物 3

HCID 160549p-Cyanobenzyl alcoholHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

生成物 1

HCID 53437716N-Hydroxy-4-(hydroxymethyl)benzimidamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of hydroxylamine hydrochloride (5.2 g), 4-(hydroxymethyl)benzonitrile (5.0 g), and sodium hydrogen carbonate (12.6 g) in methanol (50 mL) was heated to reflux for 20 hours. The reaction mixture was filtered through Celite (trade name). Thus, the filtrate was concentrated to thereby give the title compound having the following physical properties. The product was used for next reaction without further purification.

後処理

  1. temperatureto reflux for 20 hours
  2. filtrationThe reaction mixture was filtered through Celite (trade name)
  3. concentrationThus, the filtrate was concentrated

出典と根拠

ORDレコード
ord-6fc5d554ea6a4ccb8735b339b659b6ee
出典データセット
uspto-grants-2014_02
特許番号
US08653305B2

反応ノート

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