Trifluoroacetic acid → 5-Ethyl-1,3-dihydro-2H-indol-2-one

HRID 24384

反応式

HRID 24384 の反応式
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)(=O)[CH3:2].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[CH2:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)[CH3:2]

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 12052Triethylsilane2 回HCID 102196435-acetyl-2,3-dihydro-1H-indol-2-one

生成物 1

HCID 101541895-Ethyl-1,3-dihydro-2H-indol-2-one収率 71%

実験手順

5-Acetyl-2-oxindole (2 g) and 15 ml of trifluoroacetic acid in an ice bath was slowly treated with 1.8 g of triethylsilane and then stirred at room temperature for 5 hours. One ml of triethylsilane was added and stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of 5-ethyl-2-oxindole as a yellow solid.

後処理

  1. stirringstirring continued overnight
  2. filtrationthe resulting precipitate collected by vacuum filtration
  3. washwashed copiously with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-c8e3e385743e4295901d90ded8b42ade
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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