反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)N=1.[C:16]([NH:19]C1C=CC(Br)=C(C=1)C(O)=O)(=[O:18])[CH3:17].BrC1C=C(OC)C(OC)=CC=1C(O)=O>>[C:16]([NH:19][C:10]1[CH:2]=[CH:1][C:4]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:5]([CH:9]=1)[C:6]([OH:8])=[O:7])(=[O:18])[CH3:17]参加物
4
実験手順
The title compound was prepared in a manner analogous to Intermediate 70 substituting 5-acetamido-2-bromobenzoic acid for 2-bromo-4,5-dimethoxybenzoic acid. MS (ESI): mass calculated for C11H10N4O3, 246.22; m/z found 247.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.09 (t, J=2.8 Hz, 1H), 7.92-7.86 (m, 3H), 7.66 (dd, J=8.7, 3.3 Hz, 1H), 2.17 (dd, J=2.5, 1.3 Hz, 3H).
出典と根拠
- ORDレコード
- ord-46c87fffd8e24d7ca8fb268a1fdac41b
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653263B2
関連ノート
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