Piperidine → N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide

HRID 24390

反応式

[C:1]([NH:4][C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][C:10](=[O:14])[NH:11]2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH3:15][C:16]1([CH3:28])[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH:26]=O)[CH:22]=2)[O:17]1.N1CCCCC1>O>[CH3:15][C:16]1([CH3:28])[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH:26]=[C:9]3[C:8]4[C:12](=[CH:13][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=4)[NH:11][C:10]3=[O:14])[CH:22]=2)[O:17]1

参加物

反応条件

温度: 90 °C

実験手順

A mixture of 6-acetamido-2-oxindole (285 mg), 2,2-dimethylchroman-6-carboxaldehyde (285 mg) and piperidine (0.2 ml) was stirred at 90° C. overnight. The reaction mixture was cooled and diluted with 20 ml of water. The sticky solid which formed was filtered and chromatographed (2% ethanol in ethyl acetate) to give 240 mg (44%) of N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide as an orange red solid.

後処理

temperatureThe reaction mixture was cooled
customThe sticky solid which formed
filtrationwas filtered
customchromatographed (2% ethanol in ethyl acetate)

出典と根拠

ORDレコード: ord-01a3a2ad64bf410eb46cf49e157ea541
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06855730B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート