Pyridine → N-(4-fluorophenyl)acetamide

HRID 244466

反応式

HRID 244466 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:15](=[O:17])[CH3:16])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 97314-Fluoroaniline

生成物 1

HCID 9601N-(4-fluorophenyl)acetamide収率 91.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a chilled (ice-bath) solution of 4-fluorophenylamine (2.9 mL, 30 mmol) and anhydrous pyridine (3.7 mL, 45 mmol) in methylene chloride (50 mL) was slowly added a solution of acetyl chloride (2.4 mL, 33 mmol) in methylene chloride (10 mL). After 15 minutes, the mixture was concentrated in vacuo and the residue was diluted with cold water. The resulting precipitate was filtered, washed with water and dried to afford 4.2 g of N-(4-fluorophenyl)acetamide as an off white solid. MS m/z 154 (MH+).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. additionthe residue was diluted with cold water
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-e2199747741544279ac642f150d5786b
出典データセット
uspto-grants-2014_02
特許番号
US08658637B2

関連ノート

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