Pyridine → N-(4-fluorophenyl)acetamide
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:15](=[O:17])[CH3:16])=[CH:4][CH:3]=1参加物
5
実験手順
To a chilled (ice-bath) solution of 4-fluorophenylamine (2.9 mL, 30 mmol) and anhydrous pyridine (3.7 mL, 45 mmol) in methylene chloride (50 mL) was slowly added a solution of acetyl chloride (2.4 mL, 33 mmol) in methylene chloride (10 mL). After 15 minutes, the mixture was concentrated in vacuo and the residue was diluted with cold water. The resulting precipitate was filtered, washed with water and dried to afford 4.2 g of N-(4-fluorophenyl)acetamide as an off white solid. MS m/z 154 (MH+).
後処理
- concentrationthe mixture was concentrated in vacuo
- additionthe residue was diluted with cold water
- filtrationThe resulting precipitate was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-e2199747741544279ac642f150d5786b
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658637B2
反応ノート
読み込み中…