Hydrochloric Acid → 3-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol
反応式
Cl.CC1(C)[O:7][CH:6]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]([C:24]3[CH:39]=[CH:38][C:27]4[N:28]([C:31]5[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=5)[N:29]=[N:30][C:26]=4[CH:25]=3)([OH:23])[C:19]([F:22])([F:21])[F:20])=[CH:10]2)[CH2:5][O:4]1>C(#N)C>[F:21][C:19]([F:20])([F:22])[C:18]([C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:8][CH:6]([OH:7])[CH2:5][OH:4])[CH:10]=1)([C:24]1[CH:39]=[CH:38][C:27]2[N:28]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)[N:29]=[N:30][C:26]=2[CH:25]=1)[OH:23]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
At room temperature, approximately 200 μL of concentrated HCl was added to 1-[1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]ethanol (100 mg) in aqueous acetonitrile. After 90 minutes, LCMS showed one peak MS m/z 501 (MH+) for the desired product. The mixture was then concentrated and the residue diluted with sodium bicarbonate and extracted with ethyl acetate. The combined organic extracts were washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to afford 95 mg of the title compound as an off-white solid.