Sodium Azide → 4-(2-Azidoacetyl)benzonitrile

HRID 244586

反応式

HRID 244586 の反応式
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[N-:13]=[N+:14]=[N-:15].[Na+]>CO>[N:13]([CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4])=[N+:14]=[N-:15]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 986544-(Bromoacetyl)benzonitrile

生成物 1

HCID 586617294-(2-Azidoacetyl)benzonitrile収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the commercially available 4-bromoacetyl-benzonitrile (5 g, 22.32 mmol) in 150 mL of methanol was added sodium azide (1.74 g, 26.78 mmol) and the contents stirred at room temperature for 2 h. After removal of the solvent, the residue was treated with water (50 mL) and extracted with dichloromethane (3×50 mL). The combined organic layers were dried over MgSO4 and concentrated to give a yellow solid (3.90 g, 94%). This compound was used for the next step without any further purification.

後処理

  1. customAfter removal of the solvent
  2. additionthe residue was treated with water (50 mL)
  3. extractionextracted with dichloromethane (3×50 mL)
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b2c5886bde8446999e9f1ed768a4f001
出典データセット
uspto-grants-2014_02
特許番号
US08658659B2

関連ノート

読み込み中…