Sodium Hydroxide → HCID 58356323、化合物
反応式
[CH3:1][CH:2]([C:4]1[S:8][C:7]([CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[N:6][C:5]=1[C:16]([O:18]CC)=[O:17])[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([C:4]1[S:8][C:7]([CH2:9][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[N:6][C:5]=1[C:16]([OH:18])=[O:17])[CH3:1]参加物
4
反応条件
- 温度
- 20 °C
実験手順
A solution of ethyl 5-(1-methylethyl)-2-(4-morpholinylmethyl)-1,3-thiazole-4-carboxylate (77 mg) in methanol (5 ml) was treated with 2M sodium hydroxide solution (5 ml) and the mixture stirred at 20° C. for 18 h. The mixture was concentrated in vacuo and the residue taken up in water (3 ml). The pH was adjusted to pH 5-6 using 2M hydrochloric acid solution and extracted with DCM (10 ml), separated by hydrophobic frit and evaporated to give the title compound as a pale yellow gum (33 mg).