Hydrochloric Acid → 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid

A mixture of ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (278 mg) in ethanol (3.5 ml) was added 2M sodium hydroxide solution (2.4 ml) and the mixture stirred at RT for 1 h. The mixture was acidified by the addition of 2M hydrochloric acid solution (2.5 ml) and the mixture blown to dryness. The residue was treated with water (2 ml) and extracted with ethyl acetate (3×5 ml). The combined organic extracts were dried over sodium sulphate and evaporated to give the title compound (168 mg) as a beige solid.

1. extractionextracted with ethyl acetate (3×5 ml)
2. dry with materialThe combined organic extracts were dried over sodium sulphate
3. customevaporated

ORDレコード

ord-5673697bba6c4e48a09a55bfc1aef75d

出典データセット

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08658635B2