Sodium Hydroxide → HCID 58356330、化合物

HRID 244665ノート

反応式

HRID 244665 の反応式
[CH3:1][CH:2]([N:4]1[N:8]=[C:7]([C:9]([O:11]CC)=[O:10])[CH:6]=[N:5]1)[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([N:4]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[N:5]1)[CH3:1]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58356328HCID 58356328、化合物

生成物 1

HCID 58356330HCID 58356330、化合物収率 80.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of ethyl 2-(1-methylethyl)-2H-1,2,3-triazole-4-carboxylate (670 mg) in methanol (6 ml) was added sodium hydroxide (4 ml) and the mixture was stirred at room temperature for 4 h. The methanol was removed in vacuo and water (10 ml) was added and the mixture neutralised (pH 5-6) by the addition of 2M hydrochloric acid. The aqueous layer was extracted with DCM, separated by hydrophobic frit and the organic layer evaporated in vacuo to give the title compound (455 mg) as a white solid.

後処理

  1. customThe methanol was removed in vacuo and water (10 ml)
  2. additionwas added
  3. additionthe mixture neutralised (pH 5-6) by the addition of 2M hydrochloric acid
  4. extractionThe aqueous layer was extracted with DCM
  5. customseparated by hydrophobic frit
  6. customthe organic layer evaporated in vacuo

出典と根拠

ORDレコード
ord-f3b5fbbcde3d4f048cad099827632a54
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

反応ノート

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