Sodium Hydroxide → 1-(2-fluoroethyl)-1H-pyrazole-5-carboxylic acid
反応式
[F:1][CH2:2][CH2:3][N:4]1[C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=[N:5]1.[OH-].[Na+]>CO>[F:1][CH2:2][CH2:3][N:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=[N:5]1参加物
4
反応条件
- 温度
- 20 °C
実験手順
To a solution of ethyl 1-(2-fluoroethyl)-1H-pyrazole-5-carboxylate (0.2 g) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue dissolved in water (20 ml) and acidified to pH-4 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and evaporated to give the title compound (0.132 g) as a white solid.
後処理
- customThe solvent was removed in vacuo
- dissolutionthe residue dissolved in water (20 ml)
- extractionthen extracted with ethyl acetate (20 ml)
- dry with materialdried over sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-2a1e26f0048a46dd83791a805da69d54
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658635B2
反応ノート
読み込み中…