Sodium Hydroxide → HCID 58356418、化合物

HRID 244672ノート

反応式

HRID 244672 の反応式
[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([O:12]CC)=[O:11])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 50998908Ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate

生成物 1

HCID 58356418HCID 58356418、化合物収率 33.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To a solution of ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate (75 mg) (available from Butt Park Ltd.) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the mixture taken up in water (5 ml) and acidified to pH=2 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and the mixture evaporated to give the title compound (22 mg) as a yellow solid.

後処理

  1. customThe solvent was removed in vacuo
  2. extractionthen extracted with ethyl acetate (20 ml)
  3. dry with materialdried over sodium sulphate
  4. customthe mixture evaporated

出典と根拠

ORDレコード
ord-8bbcfc82b78140c4bbd1c49bf688d83e
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

反応ノート

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