Hydrochloric Acid → N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

HRID 244682ノート

反応式

HRID 244682 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:8]=[C:9]([NH2:14])[C:10]([CH3:13])=[N:11][CH:12]=1.Cl.C(Cl)Cl>N1C=CC=CC=1>[Br:6][C:7]1[CH:8]=[C:9]([NH:14][S:2]([CH3:1])(=[O:4])=[O:3])[C:10]([CH3:13])=[N:11][CH:12]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6344Dichloromethane2 回HCID 31297Methanesulfonyl chlorideHCID 219640965-Bromo-2-methylpyridin-3-amine

生成物 1

HCID 57545815N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Methanesulfonyl chloride (97 μl) was added dropwise to 5-bromo-2-methyl-3-pyridinamine (Chempacific) (200 mg) in pyridine (5 ml). The reaction was stirred at room temperature for 20 min before addition of 2M HCl (aq) (5 ml) and extraction into DCM. The DCM was passed through a hydrophobic frit then dried under a stream of nitrogen. The residue was dissolved in DCM and washed through an aminopropyl cartridge (preconditioned with DCM) with DCM to give title compound, 77 mg.

後処理

  1. customthen dried under a stream of nitrogen
  2. dissolutionThe residue was dissolved in DCM
  3. washwashed through an aminopropyl cartridge (preconditioned with DCM) with DCM

出典と根拠

ORDレコード
ord-afed0135a8b140f4b318f91a730a886e
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

反応ノート

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