Thionyl Chloride → 1-Isopropyl-1H-pyrazole-5-carbonyl chloride
反応式
S(Cl)([Cl:3])=O.[CH3:5][CH:6]([N:8]1[C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=[N:9]1)[CH3:7]>>[CH3:5][CH:6]([N:8]1[C:12]([C:13]([Cl:3])=[O:15])=[CH:11][CH:10]=[N:9]1)[CH3:7]参加物
3
反応条件
- 温度
- 80 °C
実験手順
Thionyl chloride (5 ml) was added to 1-(1-methylethyl)-1H-pyrazole-5-carboxylic acid (1 g) and the reaction was heated at 80° C. for 5 h. The reaction was evaporated, then azeotroped with toluene to give title compound, 856 mg.
後処理
- customThe reaction was evaporated
- customazeotroped with toluene
出典と根拠
- ORDレコード
- ord-270bd04e4d5e40fc80dfaf99e709ba8c
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658635B2
反応ノート
読み込み中…