N-methyl-2-oxoindoline-5-sulfonamide → 4-(3-dimethylaminopropyl)-2-methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid

HRID 24475

反応式

HRID 24475 の反応式
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[CH3:16][N:17]([CH3:32])[CH2:18][CH2:19][CH2:20][C:21]1[C:22]([C:29]([OH:31])=[O:30])=[C:23]([CH3:28])[NH:24][C:25]=1[CH:26]=O>>[CH3:32][N:17]([CH3:16])[CH2:18][CH2:19][CH2:20][C:21]1[C:22]([C:29]([OH:31])=[O:30])=[C:23]([CH3:28])[NH:24][C:25]=1[CH:26]=[C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[C:6]([S:3](=[O:5])(=[O:4])[NH:2][CH3:1])[CH:7]=2)[NH:11][C:10]1=[O:15]

参加物

3

反応物 2

HCID 10176909N-methyl-2-oxoindoline-5-sulfonamideHCID 225710744-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid

生成物 1

HCID 541495034-(3-dimethylaminopropyl)-2-methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid収率 22.4%

実験手順

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (113 mg) was condensed with 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid (119 mg) to give 50 mg 4-(3-dimethylaminopropyl)-2-methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid.

出典と根拠

ORDレコード
ord-9053dda97a26429d9d87388cdc5e7a24
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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