4-Aminophenol → 2-(4-Hydroxyphenylamino)-2-methylpropanenitrile

HRID 244966ノート

反応式

HRID 244966 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[O-]S([O-])(=O)=O.[Mg+2].[CH3:15][C:16]([CH3:20])(O)[C:17]#[N:18]>>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:16]([CH3:20])([CH3:15])[C:17]#[N:18])=[CH:3][CH:4]=1

参加物

4

反応物 3

HCID 4034-AminophenolHCID 6406Acetone CyanohydrinHCID 24083Sulfuric acid magnesium salt (1:1)

生成物 1

HCID 3502692-(4-Hydroxyphenylamino)-2-methylpropanenitrile収率 96%

反応条件

温度
80 °C

実験手順

A mixture of 4-aminophenol (1.09 g, 10 mmol), acetone cyanohydrin (10 ml) and MgSO4 (2 g) was heated to 80° C. and stirred for 4 h. After concentration of the medium under vacuum, compound 3a was crystallized from water (20 ml). The solid was filtered and dried to yield 2-(4-hydroxyphenylamino)-2-methylpropanenitrile, 3a (1.69 g, 9.6 mmol, 96%).

後処理

  1. customAfter concentration of the medium under vacuum, compound 3a was crystallized from water (20 ml)
  2. filtrationThe solid was filtered
  3. customdried

出典と根拠

ORDレコード
ord-5642086b16d940f4847fbde5012c6f54
出典データセット
uspto-grants-2014_02
特許番号
US08658681B2

反応ノート

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