Aniline → 2-Anilino-2-methylpropiononitrile

HRID 244974ノート

反応式

HRID 244974 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][C:9]([CH3:13])(O)[C:10]#[N:11]>C(OCC)(=O)C>[CH3:8][C:9]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([CH3:13])[C:10]#[N:11]

参加物

4

反応物 2

HCID 6115AnilineHCID 6406Acetone Cyanohydrin

生成物 1

HCID 751282-Anilino-2-methylpropiononitrile収率 94%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of aminobenzene (0.931 g, 10 mmol) and acetone cyanohydrin (2 ml) was heated to reflux and stirred for 20 h. After being cold to room temperature, the reaction mixture was poured into ethyl acetate (40 ml) and washed with cold water (2×30 ml). The organic layer was dried over MgSO4, concentrated under vacuum to dryness to yield 2-methyl-2-phenylaminopropanenitrile, 6a (1.51 g, 9.4 mmol, 94%) as slurry brown liquid.

後処理

  1. temperaturewas heated
  2. temperatureto reflux
  3. customAfter being cold to room temperature
  4. washwashed with cold water (2×30 ml)
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated under vacuum to dryness

出典と根拠

ORDレコード
ord-e40861c200e4438ebcdee7cebb1aa4e4
出典データセット
uspto-grants-2014_02
特許番号
US08658681B2

反応ノート

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