Dimethylamine → 3-(4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid dimethyl amide

HRID 24508

反応式

HRID 24508 の反応式
[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[C:3]([CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:2]1.C(C1NC=CN=1)([C:17]1[NH:18][CH:19]=CN=1)=O.CNC>O1CCCC1>[CH3:17][N:18]([CH3:19])[C:12](=[O:14])[CH2:11][CH2:10][C:3]1[C:4]2[CH2:5][CH2:6][CH2:7][CH2:8][C:9]=2[NH:1][CH:2]=1

参加物

5

反応物 3

HCID 674DimethylamineHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 107978613-(4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid

生成物 1

HCID 112182943-(4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid dimethyl amide収率 70%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-(4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (9.7 g) in 100 mL of tetrahydrofuran was stirred with 8.1 g of carbonyl diimidazole for 1 hour. Dimethylamine (2.5 g) was added and the mixture stirred for 2 hours. The solvent was evaporated and the residue taken up in ethyl acetate, washed with water, 0.1 N hydrochloric acid, water, and brine, dried over sodium sulfate and evaporated to give 7.7 g (70% yield) of 3-(4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid dimethyl amide.

後処理

  1. customThe solvent was evaporated
  2. washwashed with water, 0.1 N hydrochloric acid, water, and brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-4ca8e4e9161a4696b55e42daf8938e36
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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