Hydrochloric Acid → 3-[2-(2-Oxo-1,2-dihydroindol-3-ylidenemethyl)-phenyl]-propionic acid

HRID 24531ノート

反応式

HRID 24531 の反応式
[O:1]=[C:2]1[NH:3][C:4]2[C:9](/[C:10]/1=[CH:11]\[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:8][CH:7]=[CH:6][CH:5]=2.[OH-].[Na+].Cl>>[O:1]=[C:2]1[C:10](=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:18][CH2:19][C:20]([OH:22])=[O:21])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86591008ethyl (E)-3-[(2-oxo-1,2-dihydroindol-3-ylidenemethyl)phenyl]propionate

生成物 1

HCID 543002103-[2-(2-Oxo-1,2-dihydroindol-3-ylidenemethyl)-phenyl]-propionic acid収率 11%

反応条件

温度
90 °C

実験手順

To 300 mg of ethyl (E)-3-[(2-oxo-1,2-dihydroindol-3-ylidenemethyl)phenyl]-propionate in 3 mL of ethanaol was added 2 mL of 2N sodium hydroxide. The mixture was stirred at 90° C. for 2 hrs, cooled and acidified with 6 N hydrochloric acid to pH 3. The solid was collected by filtration and washed with cold ethanol to give 30 mg of 3-[2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-phenyl]-propionic acid as a yellow solid.

後処理

  1. temperaturecooled
  2. filtrationThe solid was collected by filtration
  3. washwashed with cold ethanol

出典と根拠

ORDレコード
ord-f76e9062d437402ab5c4d458d4643458
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

反応ノート

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