D-Phenylalanine → HCID 178448095、化合物

HRID 245348ノート

反応式

HRID 245348 の反応式
[CH:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10](Cl)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[NH2:13][C@@H:14]([C:22]([OH:24])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[CH3:2][CH:1]([CH3:3])[C@@H:4]1[CH2:9][CH2:8][C@@H:7]([C:10]([NH:13][C@H:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:22]([OH:24])=[O:23])=[O:11])[CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 71567D-PhenylalanineHCID 178448093HCID 178448093、化合物

生成物 1

HCID 178448095HCID 178448095、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

EP1334963A discloses a method for producing nateglinide crystals from a reaction mixture containing nateglinide. The nateglinide is obtained by reacting trans-4-isopropylcyclohexane carboxylic acid chloride with D-phenylalanine in a mixed solvent of a ketone and water in the presence of an alkali, followed by neutralisation with an acid. Specific adjustment of the temperature of the mixture and the concentration of ketone solvent results in precipitation of nateglinide crystals. The ketone solvent(s) in the reaction is usually essential to proceed the reaction. However, a large quantity of acetone in the reaction causes high proportion of by-product.

出典と根拠

ORDレコード
ord-e4967e728f3f48cfb34803717d20403b
出典データセット
uspto-grants-2014_02
特許番号
US08658821B2

反応ノート

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