Sodium Hydroxide → 6-Aminoquinoline-5-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:11]=2[CH:12]=[CH:13][C:14]=1[NH2:15])=[O:4].[OH-].[Na+]>O1CCOCC1.CO>[NH2:15][C:14]1[CH:13]=[CH:12][C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]=1[C:3]([OH:4])=[O:2]参加物
5
実験手順
To a solution of 540 mg (2.19 mmol) of the above 6-amino-quinoline-5-carboxylic acid methyl ester in 10.8 mL of dioxane and 0.54 mL of methanol is added 5.48 mL (5.48 mmol) of an aqueous solution of NaOH 1N. The reaction is stirred 24 hours at ambient temperature. Then the solvents are evaporated in vacuo and the residue is suspended in a minimum of water and precipitated at pH 6 by addition of concentrated HCl. After filtration and washing with a minimum of water the solid obtained is dried on high vacuum pump to give 245 mg (60%) of a yellowish solid; LC/MS:189/190 (M+H)+.
後処理
- customThen the solvents are evaporated in vacuo
- customprecipitated at pH 6 by addition of concentrated HCl
- filtrationAfter filtration
- washwashing with a minimum of water the solid
- customobtained
- customis dried on high vacuum pump
出典と根拠
- ORDレコード
- ord-bc97cc84b1124a5b91c68260ea187eec
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658801B2
反応ノート
読み込み中…