Oxalyl chloride → Benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate

HRID 245685ノート

反応式

HRID 245685 の反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([C:15]([OH:17])=O)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[Cl:21][C:15]([CH:13]1[CH2:14][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:12]1)=[O:17]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid

生成物 1

HCID 86674648Benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate収率 102.6%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid (21.25 mmol, 5 g) in dichloromethane (60 ml) under a nitrogen atmosphere were added N,N-dimethylformamide (1.063 mmol, 0.083 ml) and oxalyl chloride (2M solution in dichloromethane, 25.00 mmol, 12.5 ml). After stirring at room temperature for two hours the reaction mixture was concentrated in vacuo to give 5.53 gram of crude benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate.

後処理

  1. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-2168f576f3204af9ab23bec4b2d50b4c
出典データセット
uspto-grants-2014_02
特許番号
US08658794B2

反応ノート

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