Water → HCID 178502113、化合物

HRID 245761ノート

反応式

HRID 245761 の反応式
[Br:1][C:2]1[N:3]=[C:4]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)[N:5]2[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=12.C(N(CC)CC)C.[C:27](Cl)(=[O:30])[O:28][CH3:29].O>ClCCl>[CH3:29][O:28][C:27](=[O:30])[NH:19][CH2:18][C@H:15]1[CH2:16][CH2:17][C@H:12]([C:4]2[N:5]3[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]3=[C:2]([Br:1])[N:3]=2)[CH2:13][CH2:14]1

参加物

6

反応物 4

HCID 962WaterHCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 178432907HCID 178432907、化合物

生成物 1

HCID 178502113HCID 178502113、化合物収率 54.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To ((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methanamine (0.464 mmol, 150 mg) in dichloromethane (5 ml) at 0° C. were added triethylamine (0.464 mmol, 64.7 μl) and methyl carbonochloridate (0.505 mmol, 39 μl). After stirring at room temperature for one hour water was added. The organic layer separated, dried (Na2SO4) and concentrated in vacuo to give methyl((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methylcarbamate (97 mg).

後処理

  1. additionwas added
  2. customThe organic layer separated
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5361bae56cb24c0cb4083e6fbfc498ac
出典データセット
uspto-grants-2014_02
特許番号
US08658794B2

反応ノート

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