Trifluoroacetic acid → HCID 71280322、化合物

HRID 245788ノート

反応式

HRID 245788 の反応式
C(OC(=O)[NH:7][C@H:8]([CH:19]1[CH2:21][CH2:20]1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]#[N:18])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[NH2:7][C@H:8]([CH:19]1[CH2:21][CH2:20]1)[C:9]([N:11]1[CH2:12][CH2:13][CH:14]([C:17]#[N:18])[CH2:15][CH2:16]1)=[O:10]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 71279447[(R)-2-(4-cyanopiperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 71280322HCID 71280322、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

In a round-bottomed flask, [(R)-2-(4-cyanopiperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (2.71 g, 7.93 mmol) was dissolved in dichloromethane (50 ml). The solution was cooled to 0° C. and trifluoroacetic acid (18 ml, 234 mmol) was slowly added. After the addition was complete, the ice bath was removed and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was concentrated to provide 1-((R)-2-amino-2-cyclopropyl-acetyl)-piperidine-4-carbonitrile trifluoroacetate as a yellow oil which was used without further purification.

後処理

  1. additionAfter the addition
  2. customthe ice bath was removed
  3. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-132fd7700c054a4691a418451037549c
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

読み込み中…