Trifluoroacetic acid → (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

HRID 245910ノート

反応式

HRID 245910 の反応式
C(OC(=O)[NH:7][C@H:8]([CH3:13])[C:9]([F:12])([F:11])[CH3:10])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[F:11][C:9]([F:12])([CH3:10])[C@H:8]([NH2:7])[CH3:13]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86677920((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester

生成物 1

HCID 86677918(R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a round-bottomed flask, ((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester (148 mg, 0.71 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.6 ml, 20.8 mmol) was slowly added. The reaction mixture was stirred at room temperature for 1.5 h then concentrated to give (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate as a light brown oil which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-7543787c2f79473aa5d98a0a2c337a2a
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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