Trifluoroacetic acid → [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

HRID 245940ノート

反応式

HRID 245940 の反応式
C(OC(=O)[NH:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9])(C)(C)C.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>ClCCl>[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21].[NH2:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68670262(R)-tert-butyl 1-(4-(hydroxymethyl)oxazol-2-yl)ethylcarbamate

生成物 1

HCID 71280113[2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a round-bottomed flask, [(R)-1-(4-hydroxymethyl-oxazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (137 mg, 0.51 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.2 ml, 15.6 mmol) was slowly added. The reaction was stirred at room temperature for 1.5 h then concentrated to afford [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate as a brown oil which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-c2524aa9dd504d68bc535e9ec978dcc4
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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