Trifluoroacetic acid → (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

HRID 245987

反応式

HRID 245987 の反応式
C(OC(=O)[NH:7][C@H:8]([CH3:17])[CH2:9][C:10](=[O:16])[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>C(Cl)Cl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[CH2:9][C:10]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:16]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 71280091((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester

生成物 1

HCID 71280224(R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of ((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester (crude from step 1, 189 mg, 0.74 mmol) in CH2Cl2 (5 mL) was added trifluoroacetic acid (2.0 mL, 27.0 mmol). The reaction mixture was stirred at room temperature for 2 h then concentrated to give (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate as a pale yellow oil which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-5f47dedac97a4f4d8af977687f9660a6
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

関連ノート

読み込み中…