Benzylamine → 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one
反応式
NCc1ccccc1.O=C1NCCc2cc(Br)ccc21>CC(=O)O.CC(=O)O.C[O-].Cc1ccccc1.[Na+].[Pd].c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>O=C1NCCc2cc(NCc3ccccc3)ccc21参加物
7
反応条件
- 温度
- 110 °C
実験手順
In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.
出典と根拠
- ORDレコード
- ord-08bf18171af14ad9bb3d94faf7cd7b73
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
読み込み中…