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Ethyl Acetate → 6-(2-Aminoethoxymethyl)-4-(3-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3,3-diphenylpropyl)amide

HRID 24611
ノート
印刷プレビュー

反応式

HRID 24611 の反応式
C(OCC)(=O)C.[C:7]1([CH:13]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:14][CH2:15][NH:16][C:17]([C:19]2[CH:20]([C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[CH:34]=3)[NH:21][C:22](=[O:32])[NH:23][C:24]=2[CH2:25][O:26][CH2:27][CH2:28][N:29]=[N+]=[N-])=[O:18])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>[H][H].[Pd]>[C:40]1([CH:13]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:14][CH2:15][NH:16][C:17]([C:19]2[CH:20]([C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[CH:34]=3)[NH:21][C:22](=[O:32])[NH:23][C:24]=2[CH2:25][O:26][CH2:27][CH2:28][NH2:29])=[O:18])[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 207588816-(2-Azidoethoxymethyl)-4-(3-chlorophenyl)-2-oxo-1,2, 3,4-tetrahydropyrimidine-5-carboxylic acid (3,3-diphenylpropyl)amide

生成物 1

HCID 207588796-(2-Aminoethoxymethyl)-4-(3-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3,3-diphenylpropyl)amide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒
HCID 178418361
HCID 178418361、化合物
溶媒

実験手順

10 ml of ethyl acetate was added to a mixture of 180 mg (0.330 mmol) of 6-(2-azidoethoxymethyl)-4-(3-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3,3-diphenylpropyl)amide and a catalytic amount of 10% palladium/carbon, and they were stirred at room temperature in hydrogen atmosphere under normal pressure overnight. The catalyst was filtered out, and the filtrate was concentrated under reduced pressure. The residue was purified by the basic silica gel chromatography (dichloromethane/methanol=100/1 to 20/1) to obtain the title compound.

後処理

  1. filtrationThe catalyst was filtered out
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by the basic silica gel chromatography (dichloromethane/methanol=100/1 to 20/1)

出典と根拠

ORDレコード
ord-9a4aec40c46f4999a0faa280453aa97f
出典データセット
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06855716B2

反応ノート

読み込み中…

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