Trifluoroacetic acid → (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

HRID 246121ノート

反応式

HRID 246121 の反応式
C(OC(=O)[NH:7][C@H:8]([CH3:15])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[CH3:15][C@@H:8]([NH2:7])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 71279609((R)-1-methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 71279935(R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

((R)-1-Methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester (49 mg, 0.22 mmol) was dissolved in dichloromethane (2.4 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 2 h then evaporated and dried under high vacuum to afford (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate which was used without further purification.

後処理

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-4d94d1181e9045979f536c89b3a589b0
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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