Trifluoroacetic acid → (R)-3-amino-2-methyl-propionitrile trifluoroacetate
反応式
C(OC(=O)[NH:7][CH2:8][C@H:9]([C:11]#[N:12])[CH3:10])(C)(C)C.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>ClCCl>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[NH2:12][CH2:11][C@@H:9]([CH3:10])[C:8]#[N:7]参加物
4
実験手順
((R)-2-Cyano-2-methyl-ethyl)-carbamic acid tert-butyl ester (42 mg, 0.23 mmol) was dissolved in dichloromethane (1.2 ml) and cooled in an ice bath. Trifluoroacetic acid (0.7 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (R)-3-amino-2-methyl-propionitrile trifluoroacetate which was used without further purification.
後処理
- temperaturecooled in an ice bath
- customthen evaporated
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-18b095b4312b412a98cb285f2a192129
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658646B2
反応ノート
読み込み中…