Trifluoroacetic acid → (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

HRID 246132ノート

反応式

HRID 246132 の反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[O:10]1[CH2:11][CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67324694(S)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate

生成物 1

HCID 71280724(S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(S)-(Tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (42 mg, 0.21 mmol) was dissolved in dichloromethane (2.2 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate which was used without further purification.

後処理

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-fff9c8c54d0e477aaaac4c38aa4d05de
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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