Trifluoroacetic acid → (R)-2-amino-1-(3-fluoro-azetidin-1-yl)-3-methoxy-propan-1-one trifluoroacetate
反応式
C(OC(=O)[NH:7][C@H:8]([CH2:16][O:17][CH3:18])[C:9]([N:11]1[CH2:14][CH:13]([F:15])[CH2:12]1)=[O:10])(C)(C)C.[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23]>ClCCl>[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].[NH2:7][C@H:8]([CH2:16][O:17][CH3:18])[C:9]([N:11]1[CH2:14][CH:13]([F:15])[CH2:12]1)=[O:10]参加物
4
反応条件
- 温度
- 0 °C
実験手順
In a 25 mL round-bottomed flask, [(R)-2-(3-fluoro-azetidin-1-yl)-1-methoxymethyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (265 mg, 0.96 mmol) was dissolved in dichloromethane (5 ml). The reaction was cooled to 0° C. and trifluoroacetic acid (1.5 ml, 19.5 mmol) was slowly added. The reaction mixture was stirred at room temperature for 3 h then concentrated to provide (R)-2-amino-1-(3-fluoro-azetidin-1-yl)-3-methoxy-propan-1-one trifluoroacetate as a colorless viscous oil which was used without further purification.