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1-Hydroxybenzotriazole → N-[(S)-2-phenylpropionyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester

HRID 24626
ノート
印刷プレビュー

反応式

HRID 24626 の反応式
Cl.[CH3:2][O:3][C:4](=[O:22])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])=[CH:10][CH:9]=1)[NH2:6].[C:23]1([C@H:29]([CH3:33])[C:30](O)=[O:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C>CN(C=O)C.C(Cl)CCl>[CH3:2][O:3][C:4](=[O:22])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])=[CH:10][CH:9]=1)[NH:6][C:30](=[O:31])[C@H:29]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH3:33]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 27246222-Phenylpropionic acid, (+)-HCID 69377539HCID 69377539、化合物

生成物 1

HCID 53979202N-[(S)-2-phenylpropionyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester収率 79.6%

試薬・触媒・溶媒 2

HCID 11
1,2-Dichloroethane
溶媒
HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4-(2-methoxyphenyl)-L-phenylalanine methyl ester hydrochloride (0.03 g), (S)-2-phenylpropionic acid (0.014 g), EDC (0.02 g), HOBT (0.021 g) and DIEA (0.034 mL) in DMF (5 mL) was stirred at room temperature for 18 h. DMF was removed and the residue was partitioned between EtOAc and water. The organic layer was evaporated and washed sequentially with 10% citric acid, satd. NaHCO3 and brine. The resulting organic layer was dried (MgSO4), evaporated and the residue was purified by flash column chromatography (silica gel; eluent: CH2Cl2/EtOAc 9:1) to yield N-[(S)-2-phenylpropionyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester (0.031 g). ESMS: m/z 417 (MH+).

後処理

  1. customDMF was removed
  2. customthe residue was partitioned between EtOAc and water
  3. customThe organic layer was evaporated
  4. washwashed sequentially with 10% citric acid
  5. dry with materialThe resulting organic layer was dried (MgSO4)
  6. customevaporated
  7. customthe residue was purified by flash column chromatography (silica gel; eluent: CH2Cl2/EtOAc 9:1)

出典と根拠

ORDレコード
ord-7d51d67125a74d61b9dadd0cb93743d1
出典データセット
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06855843B2

反応ノート

読み込み中…

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