Trifluoroacetic acid → HCID 71280181、化合物

HRID 246280ノート

反応式

HRID 246280 の反応式
C(OC(=O)[NH:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 712805461426423-60-0

生成物 1

HCID 71280181HCID 71280181、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a 25 ml round-bottomed flask, [1-(1-hydroxy-1-methyl-ethyl)-cyclobutyl]-carbamic acid tert-butyl ester (150 mg, 0.65 mmol) was dissolved in dichloromethane (3.8 ml) and trifluoroacetic acid (1.5 ml, 19.5 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2.5 h then concentrated to give 2-(1-amino-cyclobutyl)-propan-2-ol trifluoroacetate as a light brown oil which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-0f8391747d01459a998776a704523355
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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