Trifluoroacetic acid → HCID 178506407、化合物
反応式
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9](C(OC(C)(C)C)=O)[N:8]=[C:7]2[I:20].FC(F)(F)C(O)=O>ClCCl>[F:21][CH:2]([F:1])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[I:20]参加物
4
実験手順
To a stirred solution of tert-butyl 5-(difluoromethoxy)-3-iodo-1H-indazole-1-carboxylate (410 mg, 1 mmol) in dichloromethane (10 mL) was added drop-wise trifluoroacetic acid (5 mL) at room temperature and the reaction mixture was stirred for 1 hour. The mixture was washed with NaHCO3 aqueous, and then organic was dried over Na2SO4. After filtration and concentration, 5-(difluoromethoxy)-3-iodo-1H-indazole (300 mg, 97%) was obtained as a white solid, used in the next step without further purification. MS: (M+H)+=311.
後処理
- washThe mixture was washed with NaHCO3 aqueous
- dry with materialorganic was dried over Na2SO4
- filtrationAfter filtration and concentration
出典と根拠
- ORDレコード
- ord-8ce6ca9075bf4c15bd54f5e18f9a43b0
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658646B2
反応ノート
読み込み中…