Benzyl Chloride → 5-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene

HRID 246847

反応式

HRID 246847 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-:10])=[O:9].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:13]([O:12][C:4]1[CH:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 1384663,5-Dimethyl-4-nitrophenol

生成物 1

HCID 133699565-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene収率 84.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 3,5-dimethyl-4-nitrophenol (17.6 g), benzyl chloride (20.0 g) and anhydrous K2CO3 (13.2 g) in acetone (100 ml) is stirred under reflux for 22 hours. The reaction mixture is filtered and the precipitate washed with acetone. The acetone extract is concentrated in vacuo and the residue short path distilled (160°-170° C.; 50μ) to give 22.9 grams of an orange liquid which crystallized on standing.

後処理

  1. temperatureunder reflux for 22 hours
  2. filtrationThe reaction mixture is filtered
  3. washthe precipitate washed with acetone
  4. extractionThe acetone extract
  5. concentrationis concentrated in vacuo
  6. distillationthe residue short path distilled (160°-170° C.; 50μ)

出典と根拠

ORDレコード
ord-771e103ba1a248bea994b0162b26dd0b
出典データセット
uspto-grants-1987_11
特許番号
US04704401

関連ノート

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