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Benzyl Chloride → 5-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3,5-Dimethyl-4-nitrophenol | HCID 138466 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 5-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene | HCID 13369956 | 84.5% |
反応手順
A mixture of 3,5-dimethyl-4-nitrophenol (17.6 g), benzyl chloride (20.0 g) and anhydrous K2CO3 (13.2 g) in acetone (100 ml) is stirred under reflux for 22 hours. The reaction mixture is filtered and the precipitate washed with acetone. The acetone extract is concentrated in vacuo and the residue short path distilled (160°-170° C.; 50μ) to give 22.9 grams of an orange liquid which crystallized on standing.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04704401 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-771e103ba1a248bea994b0162b26dd0b |
| 出典メモ | uspto-grants-1987_11 |