Butanedione → 3-Hydroxy-3-phenylbutan-2-one

HRID 246884

反応式

HRID 246884 の反応式
[CH3:1][C:2](=[O:6])[C:3](=[O:5])[CH3:4].[C:7]1(C)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1COCC1>[OH:5][C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:4])[C:2](=[O:6])[CH3:1]

参加物

4

反応物 2

HCID 650ButanedioneHCID 1140Toluene

生成物 1

HCID 2332203-Hydroxy-3-phenylbutan-2-one収率 56.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The Grignard reagent (6.13 moles) was added to 480 g of 2,3-butanedione dissolved in 1.95 L of THF and 3.25 L of PhMe while maintaining the temperature at -6° C.±4° C. After the reaction was complete, it was quenched with 5% sulfuric acid to pH=4.5±1, then worked up as in Example I to give 689 g of crude product. Vacuum distillation (88°-93° C., 1.2-3 mm Hg) gave 3-hydroxy-3-phenylbutan-2-one in 56.6% yield.

後処理

  1. customit was quenched with 5% sulfuric acid to pH=4.5±1
  2. customto give 689 g of crude product
  3. distillationVacuum distillation (88°-93° C., 1.2-3 mm Hg)

出典と根拠

ORDレコード
ord-137fd4167e004b4090f1c1e3bd5914c4
出典データセット
uspto-grants-1987_11
特許番号
US04704475

関連ノート

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