Sodium Iodide → 1-(5-Bromopentoxy)-2-propylbenzene

HRID 247169

反応式

HRID 247169 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])[CH2:2][CH3:3].[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(C(C)=O)C>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH2:1][CH2:2][CH3:3]

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 81001,5-DibromopentaneHCID 11430Potassium CarbonateHCID 125702-Propylphenol

生成物 1

HCID 137732081-(5-Bromopentoxy)-2-propylbenzene収率 63.7%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 90 g (0.66 mole) of 2-propylphenol, 300 g (1.30 mole) of 1,5-dibromopentane, 120 g of anhydrous potassium carbonate, and 9 g of sodium iodide in 1.2 l of methyl ethyl ketone was stirred at reflux for two days. After cooling, the mixture was filtered to remove insolubles and the filtrate was concentrated in vacuo. The residue was distilled under vacuum to give 120 g of the title compound as an analytically pure oil, b.p. 123°-125° at 0.1 mm Hg.

後処理

  1. temperatureat reflux for two days
  2. temperatureAfter cooling
  3. filtrationthe mixture was filtered
  4. customto remove insolubles
  5. concentrationthe filtrate was concentrated in vacuo
  6. distillationThe residue was distilled under vacuum

出典と根拠

ORDレコード
ord-04a6579e3fa74a67af9158d7428ad544
出典データセット
uspto-grants-1987_11
特許番号
US04705871

関連ノート

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