Methanol → 3-(3,5-Difluorophenyl)propan-1-ol

HRID 247416ノート

反応式

HRID 247416 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](O)=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.CO>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][OH:12])[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

4

反応物 2

HCID 887MethanolHCID 36694983-(3,5-Difluorophenyl)propionic acid

生成物 1

HCID 140499113-(3,5-Difluorophenyl)propan-1-ol収率 95%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Borane-tetrahydrofuran complex (0.095 mol) was added to a cooled (0°) solution of 3-(3,5-difluorophenyl)propanoic acid (0.043 mol) in tetrahydrofuran (75 ml). The reaction was stirred 2 hours at room temperature, then methanol was carefully added and the reaction was concentrated. The crude product was dissolved in ethyl ether, washed with water, dried over sodium sulfate and concentrated to yield 7 g (95%) of an oily product.

後処理

  1. additionBorane-tetrahydrofuran complex (0.095 mol) was added to
  2. concentrationthe reaction was concentrated
  3. dissolutionThe crude product was dissolved in ethyl ether
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-b6d710202a124d13b938d890da0e0c2b
出典データセット
uspto-grants-1987_11
特許番号
US04707488

反応ノート

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