Methanol → Benzeneacetic acid, alpha-ethyl-, methyl ester

HRID 247456

反応式

HRID 247456 の反応式
[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH3:17]O>C(OCC)C>[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([O:10][CH3:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 887MethanolHCID 70122-Phenylbutyric AcidHCID 24386Thionyl Chloride

生成物 1

HCID 102780Benzeneacetic acid, alpha-ethyl-, methyl ester

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 102 g. of 2-phenylbutyric acid dissolved in 1 liter of methanol was added 2 ml of thionyl chloride. The solution was allowed to stand at room temperature overnight. The solvent was removed in vacuo to yield an oil which was dissolved in diethyl ether, washed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution, dried over anhydrous potassium carbonate, and concentrated in vacuo. Distillation yielded 101 g of the title compound as a water-white oil, b.p. 62°-65°/0.5 mm, having the following elemental analysis:

後処理

  1. customThe solvent was removed in vacuo
  2. customto yield an oil which
  3. washwashed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over anhydrous potassium carbonate
  5. concentrationconcentrated in vacuo
  6. distillationDistillation

出典と根拠

ORDレコード
ord-6cb8aa009e3d4806be2a7f4eb9928fba
出典データセット
uspto-grants-1987_11
特許番号
US04707499

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