Methanol → Benzeneacetic acid, alpha-ethyl-, methyl ester
反応式
[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH3:17]O>C(OCC)C>[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([O:10][CH3:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
5
実験手順
To 102 g. of 2-phenylbutyric acid dissolved in 1 liter of methanol was added 2 ml of thionyl chloride. The solution was allowed to stand at room temperature overnight. The solvent was removed in vacuo to yield an oil which was dissolved in diethyl ether, washed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution, dried over anhydrous potassium carbonate, and concentrated in vacuo. Distillation yielded 101 g of the title compound as a water-white oil, b.p. 62°-65°/0.5 mm, having the following elemental analysis:
後処理
- customThe solvent was removed in vacuo
- customto yield an oil which
- washwashed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution
- dry with materialdried over anhydrous potassium carbonate
- concentrationconcentrated in vacuo
- distillationDistillation
出典と根拠
- ORDレコード
- ord-6cb8aa009e3d4806be2a7f4eb9928fba
- 出典データセット
- uspto-grants-1987_11
- 特許番号
- US04707499
反応ノート
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