Diethyl Ether → HCID 20159920、化合物

HRID 247582ノート

反応式

HRID 247582 の反応式
C(OC([NH:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15])=O)(C)(C)C.C(OCC)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15]

参加物

4

反応物 2

HCID 3283Diethyl EtherHCID 20159947HCID 20159947、化合物

生成物 1

HCID 20159920HCID 20159920、化合物収率 97%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

In 30 ml of trifluoroacetic acid was dissolved 6.0 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide, and left at a temperature of 20° C.~25° C. for 30 minutes. The mixrure was condensed under reduced pressure. To the reaction solution was added ethyl ether, and the crystals precipitated were separated by filtration. The crystals thus obtained were washed with ethylether to give 4.54 g of N-(4-amino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 97%.

後処理

  1. customcondensed under reduced pressure
  2. customthe crystals precipitated
  3. customwere separated by filtration
  4. customThe crystals thus obtained
  5. washwere washed with ethylether

出典と根拠

ORDレコード
ord-3edcffd21153471783dbfd4b5d0e1e4a
出典データセット
uspto-grants-1987_11
特許番号
US04709032

反応ノート

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