Acetone → N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide

HRID 247654

反応式

HRID 247654 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([NH:12][C:13](=[O:16])[CH:14]=[CH2:15])O.CC(C)=O>C1(C)C=CC(S(O)(=O)=O)=CC=1.O>[CH3:1][C:2]1[C:3]([OH:9])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH2:10][NH:12][C:13](=[O:16])[CH:14]=[CH2:15]

参加物

6

反応物 3

HCID 180AcetoneHCID 77712,4-DimethylphenolHCID 13543N-Methylolacrylamide

生成物 1

HCID 14008274N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide収率 84.9%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 962Water溶媒

実験手順

A flask equipped with a condenser and a stirrer was charged with 122 g of 2,4-dimethylphenol, 101 g of N-methylolacrylamide, 1.80 g of p-toluenesulfonic acid and 100 ml of acetone, and the mixture was reacted at 60° C. for 60 minutes with stirring. The obtained reaction mixture was poured into excess water to separate an organic layer. The organic layer was dissolved in 200 ml of methylene chloride, which was washed with three 100 ml portions of water to give 174 g of N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide.

後処理

  1. customA flask equipped with a condenser and a stirrer
  2. customthe mixture was reacted at 60° C. for 60 minutes
  3. customThe obtained reaction mixture
  4. customto separate an organic layer
  5. dissolutionThe organic layer was dissolved in 200 ml of methylene chloride
  6. washwhich was washed with three 100 ml portions of water

出典と根拠

ORDレコード
ord-855147608f414415ae4a431787888b5b
出典データセット
uspto-grants-1987_11
特許番号
US04709062

関連ノート

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