Acetone → N-(3-methyl-4-hydroxybenzyl)acrylamide

HRID 247655

反応式

HRID 247655 の反応式
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:9]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])O.Cl.CC(C)=O>O>[CH3:8][C:1]1[CH:2]=[C:3]([CH:4]=[CH:5][C:6]=1[OH:7])[CH2:9][NH:11][C:12](=[O:15])[CH:13]=[CH2:14]

参加物

6

反応物 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 335O-CresolHCID 13543N-Methylolacrylamide

生成物 1

HCID 20160031N-(3-methyl-4-hydroxybenzyl)acrylamide収率 66.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A flask was charged with 108 g of o-cresol, 101 g of N-methylolacrylamide, 5 g of 37% aqueous hydrochloric acid solution and 100 ml of acetone, and the mixture was subjected to the condensation reaction at 60° C. for 60 minutes with stirring. The obtained reaction mixture was poured into excess water to separate an organic layer. The organic layer was dissolved in 200 ml of methylene chloride, which was washed with three 100 ml portions of water to give 127 g of N-(3-methyl-4-hydroxybenzyl)acrylamide.

後処理

  1. customthe mixture was subjected to the condensation reaction at 60° C. for 60 minutes
  2. customThe obtained reaction mixture
  3. customto separate an organic layer
  4. dissolutionThe organic layer was dissolved in 200 ml of methylene chloride
  5. washwhich was washed with three 100 ml portions of water

出典と根拠

ORDレコード
ord-69e1e51af8ce4fe2be8d8ffb7ed1a3b9
出典データセット
uspto-grants-1987_11
特許番号
US04709062

関連ノート

読み込み中…