Acetone → N-(3-methyl-4-hydroxybenzyl)acrylamide
反応式
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:9]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])O.Cl.CC(C)=O>O>[CH3:8][C:1]1[CH:2]=[C:3]([CH:4]=[CH:5][C:6]=1[OH:7])[CH2:9][NH:11][C:12](=[O:15])[CH:13]=[CH2:14]参加物
6
実験手順
A flask was charged with 108 g of o-cresol, 101 g of N-methylolacrylamide, 5 g of 37% aqueous hydrochloric acid solution and 100 ml of acetone, and the mixture was subjected to the condensation reaction at 60° C. for 60 minutes with stirring. The obtained reaction mixture was poured into excess water to separate an organic layer. The organic layer was dissolved in 200 ml of methylene chloride, which was washed with three 100 ml portions of water to give 127 g of N-(3-methyl-4-hydroxybenzyl)acrylamide.
後処理
- customthe mixture was subjected to the condensation reaction at 60° C. for 60 minutes
- customThe obtained reaction mixture
- customto separate an organic layer
- dissolutionThe organic layer was dissolved in 200 ml of methylene chloride
- washwhich was washed with three 100 ml portions of water
出典と根拠
- ORDレコード
- ord-69e1e51af8ce4fe2be8d8ffb7ed1a3b9
- 出典データセット
- uspto-grants-1987_11
- 特許番号
- US04709062
反応ノート
読み込み中…